| Item |
Information |
|
Drug Groups
|
approved |
|
Description
|
Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS. [PubChem] |
| Indication |
For the treatment of fungal infections. |
| Pharmacology |
Fluconazole, a synthetic antifungal agent of the imidazole class, is used to treat vaginal candidiasis. It inhibits the fungal lanosterol 14 alpha-demethylase which thereby prevents the formation of ergosterol which is an essential component in the fungal cell membrane. |
| Toxicity |
Symptoms of overdose include hallucinations and paranoid behavior. |
| Affected Organisms |
|
| Biotransformation |
Hepatic |
| Absorption |
90% |
| Half Life |
30 hours (range 20-50 hours) |
| Protein Binding |
11 to 12% |
| Elimination |
In normal volunteers, fluconazole is cleared primarily by renal excretion, with approximately 80% of the administered dose appearing in the urine as unchanged drug. |
| Clearance |
* 0.23 mL/min/Kg [adults]
* 0.18 mL/min/Kg [In premature newborns within 36 hours of birth]
* 0.22 mL/min/Kg [In premature newborns 6 days old]
* 0.33 mL/min/Kg [In premature newborns 12 days old]
* 0.4 mL/min/kg [9 Months-13 yearsreceiving single-oral 2 mg/kg]
* 0.51 mL/min/Kg [9 Months-13 yearsreceiving single-oral 8 mg/kg]
* 0.49 mL/min/Kg [5-15 yearsreceiving multiple IV 2 mg/kg]
* 0.59 mL/min/Kg [5-15 yearsreceiving multiple IV 4 mg/kg]
* 0.66 mL/min/Kg [5-15 yearsreceiving multiple IV 8 mg/kg] |
| External Links |
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