| Item |
Information |
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Drug Groups
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approved |
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Description
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Ceforanide is a second-generation parenteral cephalosporin antibiotic. It has a longer elimination half-life than any currently available cephalosporin. Its activity is very similar to that of cefamandole, a second-generation cephalosporin, except that ceforanide is less active against most gram-positive organisms. Many coliforms, including Escherichia coli, Klebsiella, Enterobacter, and Proteus, are susceptible to ceforanide, as are most strains of Salmonella, Shigella, Hemophilus, Citrobacter and Arizona species. |
| Indication |
For the treatment of infections caused by susceptible organisms. |
| Pharmacology |
Ceforanide is a semisynthetic second-generation cephalosporin. The cephalosporins are bactericidal drugs with both gram-positive and gram-negative activity. They inhibit bacterial cell wall synthesis in a way similar to the penicillins. |
| Toxicity |
Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions. |
| Affected Organisms |
| • |
Enteric bacteria and other eubacteria |
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| Biotransformation |
The major drug elimination route was urinary excretion with 85% of the dose being excreted unchanged in the urine within 12 hr, and no metabolites with antibiotic activity were observed in urine. |
| Absorption |
Rapidly absorbed following intramuscular injection. |
| Half Life |
2.6 to 2.98 hours |
| Protein Binding |
80.6% |
| References |
| • |
Crowle AJ, Sbarbaro JA, May MH: Effects of isoniazid and of ceforanide against virulent tubercle bacilli in cultured human macrophages. Tubercle. 1988 Mar;69(1):15-25.
[Pubmed]
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| • |
Campoli-Richards DM, Lackner TE, Monk JP: Ceforanide. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. Drugs. 1987 Oct;34(4):411-37.
[Pubmed]
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| • |
Cone LA, Barton SM, Woodard DR: Treatment of scleroma with ceforanide. Arch Otolaryngol Head Neck Surg. 1987 Apr;113(4):374-6.
[Pubmed]
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| • |
Barriere SL, Mills J: Ceforanide: antibacterial activity, pharmacology, and clinical efficacy. Pharmacotherapy. 1982 Nov-Dec;2(6):322-7.
[Pubmed]
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| External Links |
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