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Phentermine

Catalog No. DB00191 Name DrugBank
CAS Number 122-09-8 Website http://www.ualberta.ca/
M. F. C10H15N Telephone (780) 492-3111
M. W. 149.2328 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 76

SYNONYMS

IUPAC name
2-methyl-1-phenylpropan-2-amine
IUPAC Traditional name
phentermine
Brand Name
Phentermine Resin 30
Tora
Lipopill
Ionamin
Mirapront
Obenix
Oby-Trim
Omnibex
Ona-Mast
Phentercot
Pre-Sate
Pro-Fast
Wyamine Sulfate
Zantryl
Adipex-P
Duromine
Fastin
Inoamin
Linyl
Lonamin
Normephentermine
Obestin-30
Ona Mast
Phentride
Teramine
Uritone
Wilpo
Synonyms
(alpha,alpha)-Dimethylphenethylamine
Phentermine Hydrochloride
Phentermine Hcl

DATABASE IDS

CAS Number 122-09-8
PubChem SID 46508515
PubChem CID 4771

PROPERTIES

Hydrophobicity(logP) 2.2
Solubility 18.6 g/L

DETAILS

Description (English)
Item Information
Drug Groups illicit; approved
Description A central nervous system stimulant and sympathomimetic with actions and uses similar to those of dextroamphetamine. It has been used most frequently in the treatment of obesity. [PubChem]
Indication For the treatment and management of obesity.
Pharmacology Phentermine is indicated in the management of exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction. Phentermine hydrochloride is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.
Toxicity LD50 is adult monkeys is 15 to 20 mg/kg. Symptoms of overdose include delirium, mania, self-injury, marked hypertension, tachycardia, arrhythmia, hyperpyrexia, convulsion, coma, and circulatory collapse.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic.
Absorption Phentermine is rapidly absorbed after oral ingestion.
Half Life 16 to 31 hours
Protein Binding Approximately 96.3%
References
Bray GA: A concise review on the therapeutics of obesity. Nutrition. 2000 Oct;16(10):953-60. [Pubmed]
Nelson DL, Gehlert DR: Central nervous system biogenic amine targets for control of appetite and energy expenditure. Endocrine. 2006 Feb;29(1):49-60. [Pubmed]
External Links
Wikipedia
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REFERENCES

  • Nelson DL, Gehlert DR: Central nervous system biogenic amine targets for control of appetite and energy expenditure. Endocrine. 2006 Feb;29(1):49-60. Pubmed
  • Bray GA: A concise review on the therapeutics of obesity. Nutrition. 2000 Oct;16(10):953-60. Pubmed