Home > Compound List > Product Information
Chlorhexidine_Molecular_structure_CAS_55-56-1)
Click picture or here to close

Chlorhexidine

Catalog No. DB00878 Name DrugBank
CAS Number 55-56-1 Website http://www.ualberta.ca/
M. F. C22H30Cl2N10 Telephone (780) 492-3111
M. W. 505.4466 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 756

SYNONYMS

IUPAC name
N-(4-chlorophenyl)-1-3-(6-{N-[3-(4-chlorophenyl)carbamimidamidomethanimidoyl]amino}hexyl)carbamimidamidomethanimidamide
IUPAC Traditional name
chlorhexidine hydrochloride
Brand Name
Prevacare R
Hexadol
Sodium Houttuyfonamide
Superspray
Peridex
Hibiclens
Hibidil
Hibisol
Hibitane
Periogard
Pharmaseal Scrub Care
Sterido
Bioscrub
Brian Care
Cida-Stat
Dyna-Hex
Exidine
Fimeil
Hibiscrub
Hibispray
Hibistat
Microderm
Nolvasan
Oro-Clense
Periochip
Rotersept
Savloclens
Savlon Babycare
Soretol
Steri-Stat
Sterilon
Tubulicid
Synonyms
Chlorhexidine Base
Chlorhexidine Gluconate
Chlorhexidinum [INN-Latin]
Clorhexidina [INN-Spanish]
Decanoylacetaldehyde Sodium Sulfide
Chlorhexidin [Czech]
Cloresidina [DCIT]

DATABASE IDS

CAS Number 55-56-1

PROPERTIES

Hydrophobicity(logP) 3
Solubility 0.08%(w/v)

DETAILS

Description (English)
Item Information
Drug Groups approved
Description A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. [PubChem]
Indication For reduction of pocket depth in patients with adult periodontitis, used as an adjunct to scaling and root planing procedures. Also for prevention of dental caries, oropharyngeal decontamination in critically ill patients, hand hygiene in health-care personnel, general skin cleanser, and catheter site preparation and care.
Pharmacology Chlorhexidine, a topical antimicrobial agent, is bactericidal. Because of its positive charge, the chlorhexidine molecule reacts with the microbial cell surface to destroy the integrity of the cell membrane. This novel mechanism of action makes it highly unlikely for the development of bacterial resistance.
Toxicity LD50= 2g/kg (human, oral); LD50= 3 g/kg (rat, oral); LD50= 2.5 g/kg (mice, oral); LD50= 21 mg/kg (male rat, IV); LD50= 23 mg/kg (female rat, IV); LD50= 25 mg/kg (male mice, IV); LD50= 24 mg/kg (female mice, IV); LD50= 1g/kg (rat, subcutaneous); LD50= 637 mg/kg (male mice, subcutaneous); LD50= 632 mg/kg (female mice, subcutaneous)
Affected Organisms
Bacteria
Absorption Absorption of chlorhexidine from the gastrointestinal tract is very poor. Additionally, an in vivo study in 18 adult patients found no detectable plasma or urine chlorhexidine concentrations following insertion of four periodontal implants under clinical conditions.
Protein Binding 87%
Elimination Excretion of chlorhexidine gluconate occurred primarily through the feces (~90%). Less than 1% of the chlorhexidine gluconate ingested by these subjects was excreted in the urine.
External Links
Wikipedia
RxList
Drugs.com

REFERENCES