Ritodrine

• Catalog No.: DB00867
• CAS Number: 26652-09-5
• M. F.: C17H21NO3
• M. W.: 287.35354

SYNONYMS

• IUPAC name: 4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol
• IUPAC Traditional name: 4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol
• Brand Name: Yutopar S.R; Yutopar
• Synonyms: Ritodrina [INN-Spanish]; Ritodrine Hydrochloride; Ritodrine Hcl; Ritodrinium [INN-Latin]

DATABASE IDS

• PubChem CID: 33572
• CAS Number: 26652-09-5
• PubChem SID: 46505273

PROPERTIES

• Hydrophobicity(logP): 2.4
• Solubility: Complete

DETAILS

Description (English)

• Drug Groups: approved
• Description: Adrenergic beta-agonist used to control premature labor. [PubChem]
• Indication: For the treatment and prophylaxis of premature labour
• Pharmacology: Beta-2 adrenergic receptors are located at sympathetic neuroeffector junctions of many organs, including uterus. Ritodrine is beta-2 adrenergic agonist. It stimulates beta-2 adrenergic receptor, increases cAMP level and decreases intracellular calcium concentration. The decrease of calcium concentration leads to a relaxation of uterine smooth muscle and, therefore, a decrease in premature uterine contractions.
• Toxicity: LD₅₀=64mg/kg (mice, IV); LD₅₀=540 mg/kg (mice, oral); LD₅₀=85 mg/kg (rat, IV)
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic, by both the mother and fetus
• Half Life: 1.7-2.6 hours
• Protein Binding: ~56%
• External Links: Wikipedia; Drugs.com