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Ritodrine

Catalog No. DB00867 Name DrugBank
CAS Number 26652-09-5 Website http://www.ualberta.ca/
M. F. C17H21NO3 Telephone (780) 492-3111
M. W. 287.35354 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 745

SYNONYMS

IUPAC name
4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol
IUPAC Traditional name
4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol
Brand Name
Yutopar S.R
Yutopar
Synonyms
Ritodrina [INN-Spanish]
Ritodrine Hydrochloride
Ritodrine Hcl
Ritodrinium [INN-Latin]

DATABASE IDS

PubChem CID 33572
CAS Number 26652-09-5
PubChem SID 46505273

PROPERTIES

Hydrophobicity(logP) 2.4
Solubility Complete

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Adrenergic beta-agonist used to control premature labor. [PubChem]
Indication For the treatment and prophylaxis of premature labour
Pharmacology Beta-2 adrenergic receptors are located at sympathetic neuroeffector junctions of many organs, including uterus. Ritodrine is beta-2 adrenergic agonist. It stimulates beta-2 adrenergic receptor, increases cAMP level and decreases intracellular calcium concentration. The decrease of calcium concentration leads to a relaxation of uterine smooth muscle and, therefore, a decrease in premature uterine contractions.
Toxicity LD50=64mg/kg (mice, IV); LD50=540 mg/kg (mice, oral); LD50=85 mg/kg (rat, IV)
Affected Organisms
Humans and other mammals
Biotransformation Hepatic, by both the mother and fetus
Half Life 1.7-2.6 hours
Protein Binding ~56%
External Links
Wikipedia
Drugs.com

REFERENCES