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Alprenolol

Catalog No. DB00866 Name DrugBank
CAS Number 13655-52-2 Website http://www.ualberta.ca/
M. F. C15H23NO2 Telephone (780) 492-3111
M. W. 249.34862 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 744

SYNONYMS

IUPAC name
{2-hydroxy-3-[2-(prop-2-en-1-yl)phenoxy]propyl}(propan-2-yl)amine
IUPAC Traditional name
alprenolol
Brand Name
Aptine
Regletin
Apllobal
Aptol Duriles
Gubernal
Yobir
Synonyms
Alprenololum [INN-Latin]
Alfeprol [Russian]
Alpheprol

DATABASE IDS

PubChem SID 46506033
CAS Number 13655-52-2
PubChem CID 2119

PROPERTIES

Hydrophobicity(logP) 2.8
Solubility 547 mg/L

DETAILS

Description (English)
Item Information
Drug Groups approved
Description One of the adrenergic beta-antagonists used as an antihypertensive, anti-anginal, and anti-arrhythmic agent. [PubChem]
Indication For the treatment of hypertension, angina, and arrhythmia
Pharmacology Alprenolol is a non-selective beta-blocker used in the treatment of hypertension, edema, ventricular tachycardias, and atrial fibrillation. Alprenolol impairs AV node conduction and decreases sinus rate and may also increase plasma triglycerides and decrease HDL-cholesterol levels. Alprenolol is nonpolar and hydrophobic, with low to moderate lipid solubility. Alprenolol has little to no intrinsic sympathomimetic activity and, unlike some other beta-adrenergic blocking agents, alprenolol has little direct myocardial depressant activity and does not have an anesthetic-like membrane-stabilizing action.
Toxicity LD50=597.0 mg/kg (Orally in rats)
Affected Organisms
Humans and other mammals
Biotransformation Hepatic. One of the active metabolites, 4-OH-alprenolol, is an active beta-blocker.
Half Life 2-3 hours
Protein Binding 80-90%

REFERENCES