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Arry-380_Molecular_structure_CAS_937265-83-3)
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Arry-380

Catalog No. S2752 Name Selleck Chemicals
CAS Number 937265-83-3 Website http://www.selleckchem.com
M. F. C29H27N7O4S Telephone (877) 796-6397
M. W. 569.63418 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 73302

SYNONYMS

IUPAC name
6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)-N-(3-methyl-4-{[1,2,4]triazolo[1,5-a]pyridin-7-yloxy}phenyl)quinazolin-4-amine
IUPAC Traditional name
6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)-N-(3-methyl-4-{[1,2,4]triazolo[1,5-a]pyridin-7-yloxy}phenyl)quinazolin-4-amine

DATABASE IDS

CAS Number 937265-83-3

PROPERTIES

Target HER2
Salt Data Free Base
Storage Condition -20°C

DETAILS

Description (English)
Research Area
Description Solid tumours , Breast cancer
Biological Activity
Description ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM.
Targets HER2 p95-HER2
IC50 8 nM 7 nM [1]
In Vitro ARRY-380 is equipotent against truncated p95-HER2 with IC50 of 7 nM. [1] However, ARRY-380 suppresses EGFR with IC50 of 4 μM. ARRY-380 is about 500-fold selective for HER2 versus EGFR. [1]
In Vivo ARRY-380 significantly prevents the growth of tumor in multiple HER2-dependent tumor xenograft models and displays additive activity in combination with standard-of-care agents. [1]
Clinical Trials ARRY-380 is in a phase I clinical trial for the treatment of breast cancer.
Features
References
[1] Moulder SL, et al. Molecular Cancer Therapeutics. 2011, 10(11), Abstracts #143.