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Quinapril hydrochloride

Catalog No. S2581 Name Selleck Chemicals
CAS Number 82586-55-8 Website http://www.selleckchem.com
M. F. C25H31ClN2O5 Telephone (877) 796-6397
M. W. 474.97704 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 73276

SYNONYMS

IUPAC name
(3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride
IUPAC Traditional name
quinapril hydrochloride hydrochloride
Synonyms
Accupril

DATABASE IDS

CAS Number 82586-55-8

PROPERTIES

Target RAAS
Salt Data hydrochloride
Storage Condition -20°C

DETAILS

Description (English)
Research Area: Neurological Disease
Biological Activity:
Quinapril hydrochloride (Accupril) is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM. Quinapril hydrochloride (Accupril) used in the treatment of hypertension and congestive heart failure. Quinapril is a prodrug. Quinapril is converted to its active metabolite, quinaprilat, in the liver. Quinapril inhibits angiotensin converting enzyme, an enzyme which catalyses the formation of angiotensin II from its precursor, angiotensin I. Angiotensin II is a powerful vasoconstrictor and increases blood pressure through a variety of mechanisms. Due to reduced angiotensin production, plasma concentrations of aldosterone are also reduced, resulting in increased excretion of sodium in the urine and increased concentrations of potassium in the blood. [1][2]References on Quinapril HCl (Accupril)[1] J Pharmacokinet Biopharm., 1998 Jun, 26(3):269-87[2] http://en.wikipedia.org/wiki/Quinapril, ,

REFERENCES

  • Akarawut W et al. J Pharmacokinet Biopharm. 1998 Jun;26(3):269-87.