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Geniposide

Catalog No. S2411 Name Selleck Chemicals
CAS Number 24512-63-8 Website http://www.selleckchem.com
M. F. C17H24O10 Telephone (877) 796-6397
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Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 73272

SYNONYMS

IUPAC name
methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4aH,5H,7aH-cyclopenta[c]pyran-4-carboxylate
IUPAC Traditional name
geniposide

DATABASE IDS

CAS Number 24512-63-8

PROPERTIES

Salt Data Free Base
Storage Condition -20°C

DETAILS

Description (English)
Research Area: Cardiovascular Disease
Biological Activity:
Geniposide is an iridoid glycoside isolated from the fruit of Gardenia jasminoides Ellis. Geniposide is one of the biologically active ingredients of gardenia fruit. Geniposide is widely used in multi-component injection in the treatment of cerebrovascular and cardiovascular diseases in China for its anti-thrombotic and anti-inflammatory effects. Geniposide exerts protective effects against hepatic steatosis in rats fed with a high fat diet; the underlying mechanism may be associated with its antioxidant actions or regulation of adipocytokine release and expression of peroxisome proliferator-activated receptor-α. Geniposide (10-20 μM) inhibited high glucose (33 mM)-induced adhesion of monocytes to HUVECs in a dose-dependent manner. Geniposide (5-40 μM) also inhibited high glucose-induced expression of VCAM-1 and E-selectin at the gene and protein levels. Furthermore, geniposide (5-20 mM) decreased reactive oxygen species production and prevented IkappaB degradation in the cytoplasm and NF-kappaB translocation from the cytoplasm to the nucleus in HUVECs. [1][2][3]References on Geniposide[1] J Zhejiang Univ Sci B., 2011 Feb, 12(2):143-8[2] J Pharm Pharmacol., 2011 Apr, 63(4):587-93[3] Acta Pharmacol Sin., 2010 Aug, 31(8):953-62

REFERENCES

  • Ma T et al. J Pharm Pharmacol. 2011 Apr; 63(4):587-93.