Acemetacin

• Catalog No.: S2602
• CAS Number: 53164-05-9
• M. F.: C21H18ClNO6
• M. W.: 415.82372
• Storage: -20°C

SYNONYMS

• IUPAC name: 2-({2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)acetic acid
• IUPAC Traditional name: ({2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl}oxy)acetic acid
• Synonyms: Emflex

DATABASE IDS

• CAS Number: 53164-05-9

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Inflammation
Biological Activity:
Acemetacin (Emflex) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.Acemetacin (Emflex) acts as a prodrug. In the body, acemetacin (Emflex) is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. An advantage of acemetacin is that it reduces gastric damage when compared to indometacin. Acemetacin (Emflex) is used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain. [1][2][3]References on Acemetacin (Emflex)[1] http://en.wikipedia.org/wiki/Acemetacin, , [2] Cochrane Database Syst Rev. , 2009 Jul 8, (3):CD007589[3] Ann Hepatol., 2009 Apr-Jun, 8(2):141-7

REFERENCES

• Chávez-Pi??a AE et al. Ann Hepatol. 2009 Apr-Jun;8(2):141-7.