Research Area: Cancer
Biological Activity:
Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker. Lacidipine (Lacipil, Motens) works by relaxing and opening up the blood vessels. [1] This allows blood to circulate more freely around the body, lowering blood pressure and allowing the heart to work more efficiently.Lacidipine (Lacipil, Motens) also inhibits Ca2+ (ER) efflux and enhances folding, trafficking, and activity of degradation-prone GC variants. Lacidipine (Lacipil, Motens) remodels mutated GC proteostasis by simultaneously activating a series of distinct molecular mechanisms, namely modulation of Ca2+ homeostasis, upregulation of the ER chaperone BiP, and moderate induction of the unfolded protein response. However, unlike previously reported proteostasis regulators, lacidipine (Lacipil, Motens) treatment is not cytotoxic but inhibits apoptosis induction typically associated with sustained activation of the unfolded protein response. [2] In another study, lacidipine pre-treatment prevents deterioration of motor nerve conduction velocity as compared to streptozotocin diabetic rats. Hyperalgesia induces by streptozotocin was antagonized by lacidipine (Lacipil, Motens). [3]References on Lacidipine (Lacipil, Motens)[1] http://en.wikipedia.org/wiki/Lacidipine, , [2] Chem Biol. , 2011 Jun 24, 18(6):766-76.[3] Arch Physiol Biochem., 2011 Feb, 117(1):12-7 |