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Carvedilol

Catalog No. S1831 Name Selleck Chemicals
CAS Number 72956-09-3 Website http://www.selleckchem.com
M. F. C24H26N2O4 Telephone (877) 796-6397
M. W. 406.47424 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 1007

SYNONYMS

IUPAC name
[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl][2-(2-methoxyphenoxy)ethyl]amine
IUPAC Traditional name
carvedilol
Synonyms
Coreg
Dilatrend

DATABASE IDS

CAS Number 72956-09-3

PROPERTIES

Target adrenergic receptor
Salt Data Free Base
Storage Condition -20°C

DETAILS

Description (English)
Biological Activity:
Carvedilol is a non-selective beta blocker/alpha-1 blocker with an IC50 of 3.8 μM for inhibition of LDL oxidation. [1] Norepinephrine stimulates the nerves that control the muscles of the heart by binding to the β1- and β2-adrenergic receptors. Carvedilol blocks the binding to those receptors, which both slows the heart rhythm and reduces the force of the heart’s pumping. This lowers blood pressure and reduces heart failure. Norepinephrine also binds to the α1-adrenergic receptors on blood vessels, causing them to constrict and raise blood pressure. Carvedilol blocks this binding to the α1-adrenergic receptors too, which also lowers blood pressure. [2]

REFERENCES

  • http://en.wikipedia.org/wiki/Carvedilol