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Sodium hydride

Catalog No. 13431 Name Alfa Aesar
CAS Number 7646-69-7 Website
M. F. Na+ Telephone
M. W. 22.98977 Fax
Purity 57-63% oil dispersion Email
Storage Chembase ID: 129527

SYNONYMS

Title
氢化钠
IUPAC name
sodium hydride
IUPAC Traditional name
sodium hydride

DATABASE IDS

MDL Number MFCD00003471
CAS Number 7646-69-7
Merck Index 148625
EC Number 231-587-3

PROPERTIES

Purity 57-63% oil dispersion
Apperance Powder
Density 0.92
Melting Point 800°C dec.
GHS Pictograms GHS02
GHS Hazard statements H260
European Hazard Symbols Flammable Flammable (F)
GHS Precautionary statements P231+P232-P280-P233-P370+P378I-P402+P404-P501A
Risk Statements 15
Safety Statements 7/8-24/25-43
Storage Warning Air & Moisture Sensitive
TSCA Listed
Hazard Class 4.3
UN Number UN1427
Packing Group I

DETAILS

REFERENCES

  • Used in the deprotonation of DMSO to form "dimsyl sodium", a useful strong base for e.g. the Wittig reaction: J. Org. Chem., 28, 1128 (1963).
  • For a review of sodium hydride-based complex reducing agents, see: Acta Chem. Scand., 44, 274 (1990).
  • Widely used strong base for the irreversible formation of Na derivatives. If required, the protective oil can be removed by repeated washing and decantation with low-boiling petroleum, see, e.g.: Org. Synth. Coll., 6, 684 (1988), but for many purposes, this is not necessary, and the oil can be removed by incorporating a suitable extraction or washing step in the work-up. There are numerous Organic Syntheses references to reactions using NaH.
  • CAUTION! Many literature procedures employ NaH in DMF, and this system is often used routinely by research workers as a 'convenient' general purpose strong base. It should be noted, especially when considering scale-up of such reactions, that thermal runaways have been observed with NaH/ DMF, with self-heating beginning at temperatures as low as 26oC in some cases: Chem. Eng. News, 60(28), 5; 60(37), 5 (1982). A similar effect was also noted with N,N-dimethylacetamide. More recently also, incidents have been reported with other dipolar aprotic solvents 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (DMPU) and Dimethyl sulfoxide (DMSO): Org. Process. Res. Dev., 7, 1030 (2003).