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Tiotropium Bromide

Catalog No. S2546 Name Selleck Chemicals
CAS Number 136310-93-5 Website http://www.selleckchem.com
M. F. C19H22BrNO4S2 Telephone (877) 796-6397
M. W. 472.41628 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 73104

SYNONYMS

IUPAC name
(1R,2R,4S,5S,7R)-7-{[2-hydroxy-2,2-bis(thiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0^{2,4}]nonan-9-ium bromide
IUPAC Traditional name
(1R,2R,4S,5S,7R)-7-{[2-hydroxy-2,2-bis(thiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0^{2,4}]nonan-9-ium bromide
Synonyms
BA 679BR
Tiopropium
Tiova
Spiriva

DATABASE IDS

CAS Number 136310-93-5

PROPERTIES

Target Muscarinic receptor
Salt Data Bromide
Storage Condition -20°C

DETAILS

Description (English)
Biological Activity:
Tiotropium Bromide(Spiriva, BA 679BR) is a synthetic quaternary ammonium antimuscarinic agent and is a muscarinic receptor antagonist.Although tiotropium Bromide(Spiriva, BA 679BR) does not display selectivity for specific muscarinic receptors, on topical application tiotropium Bromide(Spiriva, BA 679BR) acts mainly on M3 muscarinic receptors located on smooth muscle cells and submucosal glands not to produce smooth muscle contraction and mucus secretion, thus producing a bronchodilatory effect. Tiotropium Bromide(Spiriva, BA 679BR) is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease. Tiotropium Bromide(Spiriva, BA 679BR) improves symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure. [1][2]References on Tiotropium Bromide(Spiriva, BA 679BR)[] Circ J, 2006, 70: 1658 – 1660

REFERENCES

  • Kato M et al. Circ J. 2006 Dec; 70(12):1658-60.