Home > Compound List > Product Information
Phenformin hydrochloride _Molecular_structure_CAS_834-28-6)
Click picture or here to close

Phenformin hydrochloride

Catalog No. S2542 Name Selleck Chemicals
CAS Number 834-28-6 Website http://www.selleckchem.com
M. F. C10H16ClN5 Telephone (877) 796-6397
M. W. 241.72054 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 73095

SYNONYMS

IUPAC name
1-carbamimidamido-N-(2-phenylethyl)methanimidamide hydrochloride
IUPAC Traditional name
phenethylbiguanide hydrochloride

DATABASE IDS

CAS Number 834-28-6

PROPERTIES

Salt Data hydrochloride
Storage Condition -20°C

DETAILS

Description (English)
Research Area: Immunology
Biological Activity:
Phenformin hydrochloride is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class. Phenformin is a biguanide. Phenformin can increase AMPK activity without increasing AMP/ATP. In a study, in hearts treated with phenformin for 18 min and then perfused for 20 min with Krebs-Henseleit buffer, [AMP] began to increase at 26 min and AMPK activity was elevated at 36 min. In hearts treated with metformin, [AMP] was increased at 50 min and AMPK activity, phosphorylated AMPK, and phosphorylated acetyl-CoA carboxylase were elevated at 61 min. Phenformin increase AMPK activity and phosphorylation in the isolated heart. The increase in AMPK activity was always preceded by and correlated with increased cytosolic [AMP]. [1][2]References on Phenformin HCl[1] Can Fam Physician., 1968 Feb., 14(2):45-7.[2] http://en.wikipedia.org/wiki/Phenformin, ,

REFERENCES

  • http://en.wikipedia.org/wiki/Phenformin