Neohesperidin

• Catalog No.: S2332
• CAS Number: 13241-33-3
• M. F.: C28H34O15
• M. W.: 610.56056
• Storage: -20°C

SYNONYMS

• IUPAC name: (2S)-7-{[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-5-hydroxy-2-(3-hydroxy-5-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
• IUPAC Traditional name: (2S)-7-{[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-5-hydroxy-2-(3-hydroxy-5-methoxyphenyl)-2,3-dihydro-1-benzopyran-4-one

DATABASE IDS

• CAS Number: 13241-33-3

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Metabolic Disease
Biological Activity:
Neohesperidin is an antioxidant agent with an IC50 of 22.31 µg/ml in the 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay.Neohesperidin (50 mg/kg) significantly inhibited 55.0% of HCl/ethanol-induced gastric lesions, and increased the mucus content. In pylorus ligated rats, neohesperidin (50 mg/kg) significantly decreased the volume of gastric secretion and gastric acid output, and increased the pH. In addition, neohesperidin inhibited the efflux of the P-glycoprotein substrate rhodamine 123 in a concentration-dependent manner. Neohesperidin also inhibits the growth of Caco-2, CEM/ADR5000 and CCRF-CEM leukaemia cells with IC50 of 0.17, 0.17 and 0.12 mM, respectively. Neohesperidin can be isolated from ethyl acetate fractions of C. jambhiri. [1][2]

REFERENCES

• Lee JH et al. Phytother Res. 2009 Dec;23(12):1748-53.