Research Area: Cancer
Biological Activity:
Asaraldehyde (Asaronaldehyde) is a selective COX-2 inhibitor.Asaraldehyde (Asaronaldehyde) was found to be the most abundant constituent, but was totally absent in its cultured broth and its natural host, C. kanehirae wood. On feeding with the acid-digested sawdust of C. kanehirae wood or vanillin to the broth for culture, asaraldehyde (Asaronaldehyde) was produced in both cultured broths. Asaraldehyde (Asaronaldehyde) showed 3.32% of prostaglandin H endoperoxide synthase-1 (COX-1) inhibitory activity and 52.69% prostaglandin H endoperoxide synthase-2 (COX-2) inhibitory activity, respectively at 100 mg/ml. 2,4,5-trimethoxybenzaldehyde showed selectivity towards COX-2 enzyme inhibition at 100 µg/ml. The COX-2/COX-1 ratio for compound 1 was 17.68 at 100 µg/ml compared to solvent control. [1][2]References on Asaraldehyde (Asaronaldehyde)[1] Letters in Applied Microbiology, 2007, 44 :387–392[2] Phytother. Res, 2003, 17:976–979 |