Scopolamine hydrobromide

• Catalog No.: S2508
• CAS Number: 114-49-8
• M. F.: C17H22BrNO4
• M. W.: 384.26488
• Storage: -20°C

SYNONYMS

• IUPAC name: (1R,2R,4S,5S,7R)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0^{2,4}]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate hydrobromide
• IUPAC Traditional name: scopolamine hydrobromide

DATABASE IDS

• CAS Number: 114-49-8

PROPERTIES

• Salt Data: hydrobromide
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Neurological Disease
Biological Activity:
Scopolamine is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 ± 4.3 nM. It is a tropane alkaloid drug with muscarinic antagonist effects. It is among the secondary metabolites of plants from Solanaceae (nightshade) family of plants, such as henbane, jimson weed and Angel’s Trumpets (Datura resp. Brugmansia spec.), and corkwood (Duboisia species). It exerts its effects by acting as a competitive antagonist at muscarinic acetylcholine receptors, specifically M1 receptors; it is thus classified as an anticholinergic, anti-muscarinic drug. [1][2]

REFERENCES

• Sim MK et al. Eur J Pharmacol. 1990 Dec 15;189(6)