Ribavirin

• Catalog No.: S2504
• CAS Number: 36791-04-5
• M. F.: C8H12N4O5
• M. W.: 244.20468
• Storage: -20°C

SYNONYMS

• IUPAC name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
• IUPAC Traditional name: ribavirin
• Synonyms: Ribasphere; Rebetol; Copegus

DATABASE IDS

• CAS Number: 36791-04-5

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Infection
Biological Activity:
Ribavirin (Copegus) is an anti-viral agent indicated for severe RSV infection (individually), hepatitis C infection and other viral infections. In this form ribavirin interferes with RNA metabolism required for viral replication. Ribavirin 5’ mono- di- and tri-phosphates are all inhibitors of certain viral RNA-dependent RNA polymerases which are a feature of anti-sense RNA viruses. Ribavirin 5’-monophosphate inhibits cellular inosine monophosphate dehydrogenase, thereby depleting intracellular pools of GTP. Ribavirin enhances host T-cell-mediated immunity against viral infection through helping to switch the host T-cell phenotype from type 2 to type 1. [1][2]

REFERENCES

• http://en.wikipedia.org/wiki/Ribavirin