Ozagrel

• Catalog No.: S2496
• CAS Number: 82571-53-7
• M. F.: C13H12N2O2
• M. W.: 228.24658
• Storage: -20°C

SYNONYMS

• IUPAC name: (2E)-3-[4-(1H-imidazol-1-ylmethyl)phenyl]prop-2-enoic acid
• IUPAC Traditional name: (2E)-3-[4-(imidazol-1-ylmethyl)phenyl]prop-2-enoic acid

DATABASE IDS

• CAS Number: 82571-53-7

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Cardiovascular Disease
Biological Activity:
Ozagrel is a potent and selective thromboxane A2 synthetase inhibitor with an IC50 of 4 nM. It does not inhibit prostacyclin (PGI2) synthetase, cyclooxygenase or PGE2 isomerase (IC50 > 1 mM). Inhibits platelet aggregation in vitro and arachidonate-induced arterial contraction in vivo. The beneficial effects of TXAS inhibition by ozagrel include improved motor coordination after experimental stroke and antihypertensive effects in spontaneously hypertensive rats. [1][2][3]References on Ozagrel[1] http://en.wikipedia.org/wiki/Ozagrel, , [2] Jpn J Pharmacol., 1986 Jul, 41(3):393-401.[3] J Urol., 1987 Mar, 137(3):571-6.

REFERENCES

• Loo MH et al. J Urol. 1987 Mar;137(3):571-6