Olopatadine hydrochloride

• Catalog No.: S2494
• CAS Number: 140462-76-6
• M. F.: C21H24ClNO3
• M. W.: 373.87316
• Storage: -20°C

SYNONYMS

• IUPAC name: 2-[(2Z)-2-[3-(dimethylamino)propylidene]-9-oxatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-5-yl]acetic acid hydrochloride
• IUPAC Traditional name: [(2Z)-2-[3-(dimethylamino)propylidene]-9-oxatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-5-yl]acetic acid hydrochloride
• Synonyms: Allelock; Patanase; Opatanol; Pataday

DATABASE IDS

• CAS Number: 140462-76-6

PROPERTIES

• Salt Data: hydrochloride
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Immunology
Biological Activity:
Olopatadine hydrochloride(Opatanol) is a histamine blocker and mast cell stabilizer with an IC50 of 559 µM for the release of histamine. Evaluation of the interaction of olopatadine with histamine receptors revealed a relatively high affinity for the H1 receptor (Ki = 31.6 nM, pKi = 7.5 ± 0.1) but lower affinities for H2 receptors (Ki = 100 µM, pKi = 4.0 ± 0.19) and H3 receptors (Ki = 79.4 µM, pKi = 4.1 ± 0.16,). The H1 selectivity of olopatadine was superior to that of other ocularly used anti-histamines studied, such as ketotifen, levocabastine, antazoline and pheniramine. [1][2]

REFERENCES

• Sharif NA et al. J Pharmacol Exp Ther. 1996 Sep