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Olopatadine hydrochloride_Molecular_structure_CAS_140462-76-6)
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Olopatadine hydrochloride

Catalog No. S2494 Name Selleck Chemicals
CAS Number 140462-76-6 Website http://www.selleckchem.com
M. F. C21H24ClNO3 Telephone (877) 796-6397
M. W. 373.87316 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 73044

SYNONYMS

IUPAC name
2-[(2Z)-2-[3-(dimethylamino)propylidene]-9-oxatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-5-yl]acetic acid hydrochloride
IUPAC Traditional name
[(2Z)-2-[3-(dimethylamino)propylidene]-9-oxatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-5-yl]acetic acid hydrochloride
Synonyms
Allelock
Patanase
Opatanol
Pataday

DATABASE IDS

CAS Number 140462-76-6

PROPERTIES

Salt Data hydrochloride
Storage Condition -20°C

DETAILS

Description (English)
Research Area: Immunology
Biological Activity:
Olopatadine hydrochloride(Opatanol) is a histamine blocker and mast cell stabilizer with an IC50 of 559 µM for the release of histamine. Evaluation of the interaction of olopatadine with histamine receptors revealed a relatively high affinity for the H1 receptor (Ki = 31.6 nM, pKi = 7.5 ± 0.1) but lower affinities for H2 receptors (Ki = 100 µM, pKi = 4.0 ± 0.19) and H3 receptors (Ki = 79.4 µM, pKi = 4.1 ± 0.16,). The H1 selectivity of olopatadine was superior to that of other ocularly used anti-histamines studied, such as ketotifen, levocabastine, antazoline and pheniramine. [1][2]

REFERENCES

  • Sharif NA et al. J Pharmacol Exp Ther. 1996 Sep