Novobiocin sodium

• Catalog No.: S2492
• CAS Number: 1476-53-5
• M. F.: C31H35N2NaO11
• M. W.: 634.60617
• Storage: -20°C

SYNONYMS

• IUPAC name: sodium 4-[(7-{[(2R,3R,4S,5R)-4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl]oxy}-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl)carbamoyl]-2-(3-methylbut-2-en-1-yl)benzen-1-olate
• IUPAC Traditional name: sodium 4-[(7-{[(2R,3R,4S,5R)-4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl]oxy}-4-hydroxy-8-methyl-2-oxochromen-3-yl)carbamoyl]-2-(3-methylbut-2-en-1-yl)benzenolate
• Synonyms: Cathomycin; Albamycin

DATABASE IDS

• CAS Number: 1476-53-5

PROPERTIES

• Salt Data: sodium salt
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Infection
Biological Activity:
Novobiocin(Albamycin) is a very potent bacterial DNA gyrase and human organic anion transporters with Ki of of 14.87 ± 0.40 µM for hOAT1, 4.77 ± 1.12 µM for hOAT3, and 90.50 ± 7.50 µM for hOAT4. [1] Novobiocin as well as the other aminocoumarin antibiotics act as competitive inhibitors of the ATPase reaction catalysed by GyrB. The potency of novobiocin is considerably higher than that of the fluoroquinolones that also target DNA gyrase, but at a different site on the enzyme. The GyrA subunit is involved in the DNA nicking and ligation activity. [2]

REFERENCES

• Duan P et al. Drug Metab Dispos. 2009 Jun;37(6)