Nitrendipine

• Catalog No.: S2491
• CAS Number: 39562-70-4
• M. F.: C18H20N2O6
• M. W.: 360.3612
• Storage: -20°C

SYNONYMS

• IUPAC name: 3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• IUPAC Traditional name: nitrendipine

DATABASE IDS

• CAS Number: 39562-70-4

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Cardiovascular Disease
Biological Activity:
Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.It is an investigational dihydropyridine calcium-channel antagonist for the treatment of hypertension. Nitrendipine and BRL 38227 cause concentration-related inhibitions of the inositol phosphate response to histamine (100 µM). Similar maximal inhibitions were caused by each agent (55-58%). Inhibitory effect of BRL 38227 was reduced in potency (IC50 = 5.5 µM), but not magnitude, in the presence of glibenclamide (0.5 µM). [1][2]References on Nitrendipine[1] http://en.wikipedia.org/wiki/Nitrendipine, , [2] DICP., 1990 Feb, 24(2):167-75.

REFERENCES

• Santiago TM et al. DICP. 1990 Feb;24(2):167-75.