Manidipine

• Catalog No.: S2481
• CAS Number: 89226-50-6
• M. F.: C35H38N4O6
• M. W.: 610.69942
• Storage: -20°C

SYNONYMS

• IUPAC name: 3-{2-[4-(diphenylmethyl)piperazin-1-yl]ethyl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• IUPAC Traditional name: manidipine
• Synonyms: Artedil; Iperten; Manivasc; Manyper

DATABASE IDS

• CAS Number: 89226-50-6

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Cardiovascular Disease
Biological Activity:
Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. It causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. It is used clinically as an antihypertensive. [1][2] At a holding potential of −37 mV, manidipine decreased the Ca2+ current at concentrations above 0.1 nM, and abolished it at 100 nM. The voltage-dependent effect of manidipine on the Ca2+ current may explain the weak negative inotropism of manidipine in ventricular muscles, and provide an electrophysiological basis for its vascular selectivity. [3]References on Manidipine (Manyper)[1] http://en.wikipedia.org/wiki/Manidipine, ,

REFERENCES

• Cheer SM et al. Drugs. 2001;61(12):1777-99.