Fleroxacin

• Catalog No.: S2469
• CAS Number: 79660-72-3
• M. F.: C17H18F3N3O3
• M. W.: 369.3383296
• Storage: -20°C

SYNONYMS

• IUPAC name: 6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• IUPAC Traditional name: fleroxacin
• Synonyms: Quinodis; Megalocin

DATABASE IDS

• CAS Number: 79660-72-3

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Infection
Biological Activity:
Fleroxacin(Quinodis) is a new broad-spectrum fluoroquinolone. In a study, fleroxacin significantly inhibited cell proliferation in a dose- and time-dependent manner at concentrations of 50-800 microg/mL for 12, 24, and 48 hours. The inhibitory effects of fleroxacin combined with 5-FU appeared synergistic using normalized isobologram and combination index analysis. In vivo, no significant changes in bladder tumor frequency were noted between the control and fleroxacin and 5-FU groups. Significant inhibition of tumor frequency was observed only when fleroxacin was administered with 5-FU.Fleroxacin combined with 5-FU inhibited the proliferation of bladder tumor cell lines both in vitro and in vivo. This combination therapy might be applicable in clinical settings. [1]

REFERENCES

• Nishikawa T et al. Urology. 2009 Dec;74(6):1370-6