Clozapine

• Catalog No.: S2459
• CAS Number: 5786-21-0
• M. F.: C18H19ClN4
• M. W.: 326.82326
• Storage: -20°C

SYNONYMS

• IUPAC name: 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaene
• IUPAC Traditional name: 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaene
• Synonyms: Leponex; Fazaclo; Azaleptin; Clozaril

DATABASE IDS

• CAS Number: 5786-21-0

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Neurological Disease
Biological Activity:
Clozapine (Clozaril) is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis. It is an antipsychotic medication used in the treatment of schizophrenia, and is also used off-label in the treatment of bipolar disorder. Clozapine is classified as an atypical antipsychotic drug because its profile of binding to serotonergic as well as dopamine receptors; its effects on various dopamine mediated behaviors also differ from those exhibited by more typical antipsychotics. [1][2]

REFERENCES

• Kuoppam?ki M et al. Eur J Pharmacol. 1993 Apr 15