Chlorpromazine hydrochloride

• Catalog No.: S2456
• CAS Number: 69-09-0
• M. F.: C17H20Cl2N2S
• M. W.: 355.3251
• Storage: -20°C

SYNONYMS

• IUPAC name: [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine hydrochloride
• IUPAC Traditional name: chlorpromazine hydrochloride
• Synonyms: Klorpromex; Chloractil; Sonazine; Promacid

DATABASE IDS

• CAS Number: 69-09-0

PROPERTIES

• Salt Data: hydrochloride
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Neurological Disease
Biological Activity:
Chlorpromazine (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 µM for nward-rectifying K+ currents and time-independent outward currents.In inhibits prolactin release inhibitory factor, thus stimulating the release of prolactin.  The turnover of dopamine in the brain is also increased. [1] Chlorpromazine blocks a variety of K+ channels in heart muscle cells. Inasmuch as the potency of inhibition is less than the previously reported use-dependent block of Na+ channels, the cardiovascular adverse effects of chlorpromazine are probably caused mainly by the latter effect. [2]

REFERENCES

• http://en.wikipedia.org/wiki/Chlorpromazine