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Sodium Danshensu

Catalog No. S2401 Name Selleck Chemicals
CAS Number 67920-52-9 Website http://www.selleckchem.com
M. F. C9H9NaO5 Telephone (877) 796-6397
M. W. 220.15453 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 73021

SYNONYMS

IUPAC name
sodium 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate
IUPAC Traditional name
sodium 3-(3,4-dihydroxyphenyl)lactate

DATABASE IDS

CAS Number 67920-52-9

PROPERTIES

Salt Data Sodium salt
Storage Condition -20°C

DETAILS

Description (English)
Research Area: Neurological Disease
Biological Activity:
Sodium Danshensu is a mono sodium of danshensu which is a compound isolated from Salvia miltiorrhiza Bge. Sodium danshensucan can significantly regulate PXR and CYP3A4. In thoracic arteries under basal tonus, sodium danshensu (0.3-3 g/L) produced a dose-dependent transient contraction. In phenylephrine-precontracted thoracic arteries with or without endothelium, low concentration (0.1-0.3 g/L) of sodium danshensu produced a weak contraction, while high concentrations (1-3 g/L) produced a pronounced vasodilator after a transient vasocontraction. Pre-incubation with sodium danshensu could inhibit vessel contraction induced by phenylephrine and potassium chloride in a concentration-dependent way. Sodium danshensu inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium. Pre-incubation with tetraethylammonium, a non-selective K+ channel blocker, and apamin, a small-conductance calcium-activated K+ channel blocker partially antagonized the relaxation response induced by sodium danshensu. [1][2]

REFERENCES

  • Zhang N et al. Acta Pharmacol Sin. 2010 Apr;31(4):421-8.