Home > Compound List > Product Information
Quercetin(Sophoretin)_Molecular_structure_CAS_117-39-5)
Click picture or here to close

Quercetin(Sophoretin)

Catalog No. S2391 Name Selleck Chemicals
CAS Number 117-39-5 Website http://www.selleckchem.com
M. F. C15H10O7 Telephone (877) 796-6397
M. W. 302.2357 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 3829

SYNONYMS

IUPAC name
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one
IUPAC Traditional name
quercetin
Synonyms
Sophoretin
Quercetine
Meletin

DATABASE IDS

CAS Number 117-39-5

PROPERTIES

Target PI3K / PKC / Src-bcr
Salt Data Free Base
Storage Condition -20°C

DETAILS

Description (English)
Research Area: Cancer
Biological Activity:
Quercetin (Sophoretin) is a PI3K and PKC inhibitor with IC50 of 3.8 μM and 15µg/ml. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. [1][2] Quercetin is a naturally-occurring polar auxin transport inhibitor with IC50 of 0.8, 16.7, 6.1, 11.36 µM for the inhibition of LDH% release, the inhibition of TNF-induced PMN-EC adhesion, TNF-induced inhibition of DNA synthesis and proliferation. It is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. [3]References on Quercetin (Sophoretin)[1] Mol Pharmacol, 2001, 59:1138–1146[2] Fitoterapia, 2010, 81:75–80

REFERENCES

  • Sidhu JS et al. Mol Pharmacol. 2001 May; 59(5):1138-46.