Dioscin(Collettiside III)

• Catalog No.: S2379
• CAS Number: 19057-60-4
• M. F.: C45H72O16
• M. W.: 869.04358
• Storage: -20°C

SYNONYMS

• IUPAC name: (2S,3R,4R,5R,6S)-2-{[(2R,3S,4S,5R,6R)-4-hydroxy-2-(hydroxymethyl)-6-[(1'S,2R,2'S,4'S,5R,7'S,8'R,9'S,12'S,13'R,16'S)-5,7',9',13'-tetramethyl-5'-oxaspiro[oxane-2,6'-pentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosan]-18'-eneoxy]-5-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-3-yl]oxy}-6-methyloxane-3,4,5-triol
• IUPAC Traditional name: dioscin
• Synonyms: Collettiside III; CCRIS 4123

DATABASE IDS

• CAS Number: 19057-60-4

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Cancer
Biological Activity:
Dioscin(Collettiside III) is extracted and isolated from Polygonatum Zanlanscianense Pamp with  IC50 of 2.6, 0.8, 7.5, and 4.5 μM for the inhibition of the growth of the MDA-MB-435, H14, HL60, and HeLa cell lines, respectively. Hela cells underwent apoptosis in dose- and time-dependent manners when treated with Dioscin. Caspase-3, -8 and -9 activities were also detected. The low enzymatic activity of caspase-8 and high activity of caspase-9 showed that the mitochondrial pathway was activated in apoptosis. [1] [2]

REFERENCES

• Cai J et al. Biol Pharm Bull. 2002 Feb;25(2):193-6.