Aloin(Barbaloin)

• Catalog No.: S2375
• CAS Number: 1415-73-2
• M. F.: C21H22O9
• M. W.: 418.39398
• Storage: -20°C

SYNONYMS

• IUPAC name: (10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9,10-dihydroanthracen-9-one
• IUPAC Traditional name: (10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one
• Synonyms: Barbaloin

DATABASE IDS

• CAS Number: 1415-73-2

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Cancer
Biological Activity:
Aloin(Barbaloin) is a potent tyrosinase inhibitor with an IC50 of 97 µM for HeLaS3 cells. It is used as a stimulant-laxative, treating constipation by inducing bowel movements.It also shows a pronounced antiproliferative effect at physiological concentration, causes cell cycle arrest in the S phase, and markedly increases HeLaS3 cell apoptosis (to 24%). In the concentration range of 20-100 µM, its action was accompanied by remarkable changes in the activity of almost all antioxidant enzymes: MnSOD activity was increased many fold, while CuZnSOD and iNOS activities were inhibited. Moreover, inhibition of CuZnSOD was shown to occur by direct aloin interaction with the enzyme. [1][2]

REFERENCES

• Ni??iforovi?? A et al. Cancer Biol Ther. 2007 Aug;6(8):1200-5.