Nalidixic Acid

• Catalog No.: S2328
• CAS Number: 389-08-2
• M. F.: C12H12N2O3
• M. W.: 232.23528
• Storage: -20°C

SYNONYMS

• IUPAC name: 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
• IUPAC Traditional name: nalidixic acid
• Synonyms: NegGram; Uronidix; Nevigramon; Nalidixin

DATABASE IDS

• CAS Number: 389-08-2

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Infection
Biological Activity:
Nalidixic acid(NegGram) is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase. Evidence exists that the active metabolite, hydroxynalidixic acid, binds strongly, but reversibly, to DNA, interfering with synthesis of RNA and, consequently, with protein synthesis. [1]

REFERENCES

• http://www.drugbank.ca/drugs/DB00779