Hyodeoxycholic acid

• Catalog No.: S2311
• CAS Number: 83-49-8
• M. F.: C24H40O4
• M. W.: 392.572
• Storage: -20°C

SYNONYMS

• IUPAC name: (4R)-4-[(1S,2R,5R,7R,8S,10S,11S,14R,15R)-5,8-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]pentanoic acid
• IUPAC Traditional name: hyodeoxycholic acid
• Synonyms: 3α; 6α-Dihydroxy-5β-cholan-24-oic acid; HDCA

DATABASE IDS

• CAS Number: 83-49-8

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Metabolic Disease
Biological Activity:
Hyodeoxycholic(HDCA) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria. In rat intestinal microflora hyodeoxycholic acid is produced by a gram-positive rod—termed HDCA-1—from several isomers of hyocholic acid and muricholic acid. In pigs with a normal gastrointestinal flora the majority of hyodeoxycholic acid found in bile is of secondary nature, but a small amount was also found in germ free pigs, which supports the hypothesis that HDCA may be a primary bile acid in this species. In healthy humans only traces of HDCA have been found in urine, but in patients with cholestatic liver disease or intestinal malabsorption a significant amount has been found excreted. Hyodeoxycholic acid undergoes glucuronidation in human liver and kidneys. [1]

REFERENCES

• http://en.wikipedia.org/wiki/Hyodeoxycholic_acid