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Hyodeoxycholic acid

Catalog No. S2311 Name Selleck Chemicals
CAS Number 83-49-8 Website http://www.selleckchem.com
M. F. C24H40O4 Telephone (877) 796-6397
M. W. 392.572 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 72951

SYNONYMS

IUPAC name
(4R)-4-[(1S,2R,5R,7R,8S,10S,11S,14R,15R)-5,8-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]pentanoic acid
IUPAC Traditional name
hyodeoxycholic acid
Synonyms
6α-Dihydroxy-5β-cholan-24-oic acid
HDCA

DATABASE IDS

CAS Number 83-49-8

PROPERTIES

Salt Data Free Base
Storage Condition -20°C

DETAILS

Description (English)
Research Area: Metabolic Disease
Biological Activity:
Hyodeoxycholic(HDCA) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria. In rat intestinal microflora hyodeoxycholic acid is produced by a gram-positive rod—termed HDCA-1—from several isomers of hyocholic acid and muricholic acid. In pigs with a normal gastrointestinal flora the majority of hyodeoxycholic acid found in bile is of secondary nature, but a small amount was also found in germ free pigs, which supports the hypothesis that HDCA may be a primary bile acid in this species. In healthy humans only traces of HDCA have been found in urine, but in patients with cholestatic liver disease or intestinal malabsorption a significant amount has been found excreted. Hyodeoxycholic acid undergoes glucuronidation in human liver and kidneys. [1]

REFERENCES

  • http://en.wikipedia.org/wiki/Hyodeoxycholic_acid