Dihydroartemisinin

• Catalog No.: S2290
• CAS Number: 71939-50-9
• M. F.: C15H24O5
• M. W.: 284.34806
• Storage: -20°C

SYNONYMS

• IUPAC name: (1R,4S,5R,8S,9R,10R,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecan-10-ol
• IUPAC Traditional name: (1R,4S,5R,8S,9R,10R,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecan-10-ol

DATABASE IDS

• CAS Number: 71939-50-9

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Infection
Biological Activity:
Dihydroartemisinin (DHA) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua. It is the active metabolite of all artemisinin compounds.  It is recommended as the first-line anti-malarial drug with low toxicity. DHA has been shown to possess promising anticancer activities and induce cancer cell death through apoptotic pathways. [1] It is also a drug used to treat malaria. The lactone of artemisinin could selectively be reduced with mild hydride-reducing agents, such as sodium borohydride, potassium borohydride, and lithium borohydride to dihydroartemisinin (a lactol) in over 90% yield. [2]

REFERENCES

• http://en.wikipedia.org/wiki/Dihydroartemisinin