Cinchonidine

• Catalog No.: S2282
• CAS Number: 485-71-2
• M. F.: C19H22N2O
• M. W.: 294.39078
• Storage: -20°C

SYNONYMS

• IUPAC name: (R)-[(2S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](quinolin-4-yl)methanol
• IUPAC Traditional name: (8a α,9R)-cinchonan-9-ol

DATABASE IDS

• CAS Number: 485-71-2

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Infection
Biological Activity:
Cinchonidine is an alkaloid used in asymmetric synthesis in organic chemistry. It is a stereoisomer and pseudo-enantiomer of cinchonine. [1] Cinchonidine beta-resorcylate was active; all mice were cured at 1 mmol/kg and the mean survival time was 13.8 +/- 2.4 days after a subcutaneous treatment at 0.5 mmol/kg in a single dose. In the series of acridines, (N-alpha, sigma-dioxopentyl)-5-amino-1,2,3,4-tetrahydroacridine cured all mice at 50 mumol/kg under the same conditions. The maximum tolerated doses in mice ranged from 100 to 150 mumol/kg for these acridine derivatives. [2]

REFERENCES

• Loiseau PM et al. Trop Med Int Health. 1996 Jun;1(3):379-84.