Asiatic acid

• Catalog No.: S2266
• CAS Number: 464-92-6
• M. F.: C30H48O5
• M. W.: 488.69912
• Storage: -20°C

SYNONYMS

• IUPAC name: (1S,2R,4aS,6aS,6bR,8aR,9R,10R,11R,12aR,12bR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid
• IUPAC Traditional name: asiatic acid

DATABASE IDS

• CAS Number: 464-92-6

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Cancer
Biological Activity:
Asiatic acid is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing. It is a neuroprotectant and inducer of apoptosis in HepG2 human hepatoma cells. It was likely to confine the breast cancer cells in the S-G2/M phase mainly through the p38 pathway, because both SB203580 and p38 small interfering RNA (siRNA) inhibition significantly attenuated the accumulation of inactive phospho-Cdc2 and phospho-Cdc25C proteins and the cell numbers of S-G2/M phase. [1]References on Asiatic acid[1] J Pharmacol Exp Ther., 2005 Apr, 313(1):333-44.

REFERENCES

• Hsu YL et al. J Pharmacol Exp Ther. 2005 Apr;313(1):333-44.