Ethyl isocyanoacetate

• Catalog No.: L15379
• CAS Number: 2999-46-4
• M. F.: C5H7NO2
• M. W.: 113.11458
• Purity: 98%

SYNONYMS

• Title: 异氰乙酸乙酯
• IUPAC name: ethyl 2-isocyanoacetate
• IUPAC Traditional name: ethyl 2-isocyanoacetate
• Synonyms: Isocyanoacetic acid ethyl ester

DATABASE IDS

• Beilstein Number: 3588613
• EC Number: 221-077-9
• MDL Number: MFCD00000007
• CAS Number: 2999-46-4

PROPERTIES

• Purity: 98%
• Boiling Point: 194-196°C
• Density: 1.035
• Flash Point: 84°C(183°F)
• Refractive Index: 1.4220
• GHS Hazard statements: H331-H302-H312-H315-H319-H335-H227
• European Hazard Symbols: X
• GHS Precautionary statements: P210-P305+P351+P338-P302+P352-P321-P405-P501A
• Risk Statements: 20/21/22-36/37/38
• Safety Statements: 9-26-36/37
• Storage Warning: Moisture & Light Sensitive
• TSCA Listed: 否
• Hazard Class: 6.1
• UN Number: UN2810
• Packing Group: III

REFERENCES

• The method has been extended to nitroaromatics, leading to pyrroles and porphyrins fused with aromatic rings: J. Chem. Soc., Perkin 1, 417 (1996).
• Base-catalyzed Michael addition to nitroalkenes provides a route to substituted pyrroles, valuable as intermediates for porphyrin synthesis: J. Chem. Soc., Chem. Commun., 1098 (1985); Tetrahedron, 46, 7483, 7587 (1990); Org. Synth. Coll., 9, 242 (1998).
• The terminal carbon also undergoes nucleophilic attack on an acyl chloride to give an ɑ-keto imidoyl chloride, which cyclizes in base to a 2-acyl-5-ethoxy oxazole: Synth. Commun., 26, 1149 (1996).