4-Methylumbelliferone(4-MU)

• Catalog No.: S2256
• CAS Number: 90-33-5
• M. F.: C10H8O3
• M. W.: 176.16872
• Storage: -20°C

SYNONYMS

• IUPAC name: 7-hydroxy-4-methyl-2H-chromen-2-one
• IUPAC Traditional name: 4-methylumbelliferone
• Synonyms: 4-MU

DATABASE IDS

• CAS Number: 90-33-5

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Cancer
Biological Activity:
4-Methylumbelliferone(4-MU) is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM. 4-MU inhibited proliferation, motility, and invasion of DU145, PC3-ML, LNCaP, C4-2B, and/or LAPC-4 cells. At IC(50) for HA synthesis (0.4 mM), 4-MU induced >3-fold apoptosis in prostate cancer cells, which could be prevented by the addition of HA. The anticancer effects of 4-MU, an orally bioavailable and relatively nontoxic agent, are primarily mediated by inhibition of HA signaling. [1][2] 

REFERENCES

• Kultti A et al. Exp Cell Res. 2009 Jul 1;315(11):1914-23