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(-)-Huperzine A_Molecular_structure_CAS_102518-79-6)
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(-)-Huperzine A

Catalog No. S2251 Name Selleck Chemicals
CAS Number 102518-79-6 Website http://www.selleckchem.com
M. F. C15H18N2O Telephone (877) 796-6397
M. W. 242.31622 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 72912

SYNONYMS

IUPAC name
(1R,9R)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.0^{2,7}]trideca-2(7),3,10-trien-5-one
IUPAC Traditional name
(1R,9R)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.0^{2,7}]trideca-2(7),3,10-trien-5-one

DATABASE IDS

CAS Number 102518-79-6

PROPERTIES

Salt Data Free Base
Storage Condition -20°C

DETAILS

Description (English)
Research Area: Neurological Disease
Biological Activity:
(-)-Huperzine A is an Acetylcholinesterase inhibitor and NMDA receptor antagonist with an IC50 of 126 μM for NMDA-induced current. Huperzine A, is a naturally occurring sesquiterpene alkaloid compound found in the plant firmoss Huperzia serrata. The IC(50) values of huperzine A were neither altered by changing the concentrations of glycine (2-0.2 μM) and pH (7.4-6.7) in the external solution, nor by addition of Zn(2+) (5 μM) and dithiothreitol (5 mM) to the external solution. [1][2]References on (-)-Huperzine A[1] http://en.wikipedia.org/wiki/Huperzine_A, , [2] Neuroscience., 2001, 105(3):663-9.

REFERENCES

  • Zhang JM et al. Neuroscience. 2001;105(3):663-9.