PIK-293

• Catalog No.: S2207
• CAS Number: 900185-01-5
• M. F.: C22H19N7O
• M. W.: 397.43256
• Storage: -20°C

SYNONYMS

• IUPAC name: 2-({4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl}methyl)-5-methyl-3-(2-methylphenyl)-3,4-dihydroquinazolin-4-one
• IUPAC Traditional name: 2-({4-aminopyrazolo[3,4-d]pyrimidin-1-yl}methyl)-5-methyl-3-(2-methylphenyl)quinazolin-4-one

DATABASE IDS

• CAS Number: 900185-01-5

PROPERTIES

• Target: PI3K
• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area

• Description: Cancer

Biological Activity

• Description: PIK-293 is a PI3-K inhibitor for p110α, p110β, p110δ and p110γ with IC50 of 100 μM, 25 μM, 0.24 μM and 10 μM, respectively.
• Targets: p110α; p110β; p110δ; p110γ
• IC50: 100 μM; 25 μM; 0.24 μM; 10 μM ^[1]
• In Vitro: PIK-293 is a pyrazolopyrimidine analog of IC87114. PIK-293 is synthesized by replacing the adenine of IC87114 with the isosteric pyrazolopyrimidine. ^[1]

References

• References: [1] Knight ZA et al. Cell, 2006, 125(4), 733-747.

REFERENCES

• Knight ZA et al. Cell, 2006, 125(4), 733-747.