3-Hydroxypropionitrile

• Catalog No.: L12570
• CAS Number: 109-78-4
• M. F.: C3H5NO
• M. W.: 71.0779
• Purity: 98%

SYNONYMS

• Title: 3-羟基丙腈
• IUPAC name: 3-hydroxypropanenitrile
• IUPAC Traditional name: ethylene cyanohydrin
• Synonyms: Ethylene cyanohydrin; 2-Cyanoethanol

DATABASE IDS

• Merck Index: 143794
• Beilstein Number: 635773
• MDL Number: MFCD00002826
• CAS Number: 109-78-4
• EC Number: 203-704-8

PROPERTIES

• Purity: 98%
• Boiling Point: 227-228°C
• Density: 1.041
• Flash Point: 128°C(262°F)
• Melting Point: -46°C
• Refractive Index: 1.4250
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• Risk Statements: 36/37/38
• RTECS: MU5250000
• Safety Statements: 26-37
• TSCA Listed: 是

REFERENCES

• Protection of carboxylic acids as 2-cyanoethyl esters can be accomplished by DCC-DMAP coupling. The esters can be cleaved with TBAF in DMF-THF: Chem. Pharm. Bull., 42, 147 (1994), or Na₂S in methanol: Chem. Pharm. Bull., 42, 1579 (1994).
• Can also be used to protect the phosphate group, by condensation with 2,4,6-Triisopropylbenzenesulfonyl chloride, A11458: Chem. Pharm. Bull.,25, 2844 (1977), or DCC: J. Am. Chem. Soc., 83, 159 (1961). Cleavage can be effected with an amine: Tetrahedron Lett., 23, 5119 (1982), ammonia: J. Org. Chem., 59, 2482 (1994); Tetrahedron Lett., 35, 4311 (1994), or TBAF: Tetrahedron Lett., 1255 (1976).
• Precursor of 2-cyanoethyl 2,2,2-trichloroethyl phosphorochloridate, a reagent for the phosphorylation of nucleosides: Synthesis, 831 (1980); see 2,2,2-Trichloroethanol, L08163.