1-Propylphosphonic acid cyclic anhydride

• Catalog No.: L11911
• CAS Number: 68957-94-8
• M. F.: C9H21O6P3
• M. W.: 318.180723
• Purity: 50+% soln. in ethyl acetate

SYNONYMS

• Title: 1-丙基磷酸环酐
• IUPAC name: tripropyl-1,3,5,2λ^5,4λ^5,6λ^5-trioxatriphosphinane-2,4,6-trione
• IUPAC Traditional name: tripropyl-1,3,5,2λ^5,4λ^5,6λ^5-trioxatriphosphinane-2,4,6-trione
• Synonyms: T3P; 1-Propanephosphonic acid cyclic anhydride

DATABASE IDS

• CAS Number: 68957-94-8
• MDL Number: MFCD00006583
• EC Number: 422-210-5
• Beilstein Number: 5079255

PROPERTIES

• Purity: 50+% soln. in ethyl acetate
• Boiling Point: 77°C
• Density: 1.080
• Flash Point: -3°C(26°F)
• Refractive Index: 1.4190
• GHS Hazard statements: H225-H314-H336
• European Hazard Symbols: Corrosive (C)
• European Hazard Symbols: Flammable (F)
• GHS Precautionary statements: P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A
• Risk Statements: 11-34-67
• Safety Statements: 16-23-26-36/37/39-45
• Storage Warning: Moisture Sensitive
• TSCA Listed: 否
• Hazard Class: 3
• UN Number: UN2924
• Packing Group: II

REFERENCES

• Condensation agent in formation of amide and ester linkages. In peptide synthesis, gives high yields, low racemization, and minimization of side reactions without the need for additives, as well as easily removable (water soluble) by-products: Angew. Chem. Int. Ed., 19, 133 (1980). Also reported for formation of a Weinreb amide in high yield from the acid and N,O-dimethylhydroxylamine: Angew. Chem. Int. Ed., 36, 1191 (1997). Activating agent for epoxidation of alkenes, giving cis-stereoselectivity in reactions with allylic alcohols: Tetrahedron Lett., 35, 8125 (1994). For a brief reviews of the reagent, see: Synlett, 1369 (2000); 1328 (2007). For peptide reagents, see Appendix 6.
• T3P is a registered trademark of Clariant Group.