Pramipexole dihydrochloride monohy

• Catalog No.: S2011
• CAS Number: 191217-81-9
• M. F.: C10H21Cl2N3OS
• M. W.: 302.26424
• Storage: -20°C

SYNONYMS

• IUPAC name: (6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrate dihydrochloride
• IUPAC Traditional name: pramipexole hydrate dihydrochloride
• Synonyms: Mirapexin; Mirapex; Sifrol

DATABASE IDS

• CAS Number: 191217-81-9

PROPERTIES

• Salt Data: Coordination Co
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Neurological Disease
Biological Activity:
Pramipexole is a partial/full D2S, D2L, D3, D4, receptor agonist with a Ki of 3.9, 2.2, 0.5, 5.1 nM. It also possesses low/insignificant affinity (500-10,000 nM) for the 5-HT1A, 5-HT1B, 5-HT1D, and α2-adrenergic receptors. It has negligible affinity (>10,000 nM) for the D1, D5, 5-HT2, α1-adrenergic, β-adrenergic, H1, and mACh receptors. It is a non-ergoline dopamine agonist indicated for treating early-stage Parkinson’s disease (PD) and restless legs syndrome (RLS). [1][2][3]

REFERENCES

• http://en.wikipedia.org/wiki/Pramipexole