Tamoxifen Citrate

• Catalog No.: S1972
• CAS Number: 54965-24-1
• M. F.: C32H37NO8
• M. W.: 563.63808
• Storage: -20°C

SYNONYMS

• IUPAC name: (2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine; 2-hydroxypropane-1,2,3-tricarboxylic acid
• IUPAC Traditional name: citro; tamoxifen
• Synonyms: Nolvadex; Valodex; Istubal

DATABASE IDS

• CAS Number: 54965-24-1

PROPERTIES

• Salt Data: Citrate
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Endocrinology
Biological Activity:
Tamoxifen Citrate (Nolvadex) is an estrogen receptor antagonist with an IC50 of 31 μM for the MCF-7 cells. In some tissues such as the endometrium, it behaves as an agonist, hence tamoxifen may be characterized as a mixed agonist/antagonist. It has been the standard endocrine (anti-estrogen) therapy for hormone-positive early breast cancer in pre-menopausal women, although aromatase inhibitors have been proposed. [1][2]References on Tamoxifen Citrate (Nolvadex)[] Journal of Steroid Biochemistry & Molecular Biology, 2003, 84 ：255–257

REFERENCES

• Seeger H et al. J Steroid Biochem Mol Biol. 2003