Phenindione

• Catalog No.: S1921
• CAS Number: 83-12-5
• M. F.: C15H10O2
• M. W.: 222.2387
• Storage: -20°C

SYNONYMS

• IUPAC name: 2-phenyl-2,3-dihydro-1H-indene-1,3-dione
• IUPAC Traditional name: phenindione
• Synonyms: Rectadione; Dindevan

DATABASE IDS

• CAS Number: 83-12-5

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Immunology, Cardiovascular Disease
Biological Activity:
Phenindione(Rectadione) is an anticoagulant which functions as a Vitamin K antagonist. A lymphocyte transformation test showed proliferation of T-cells from the hypersensitive patient, but not from four controls on exposure to phenindione in vitro. Drug-specific T-cell clones were generated and characterized in terms of their phenotype, functionality, and mechanism of antigen presentation. Forty-three human leukocyte antigen class II restricted CD4+ αβ T-cell clones were identified. T-cell activation resulted in the secretion of interferon-γ and interleukin-5. [1][2]

REFERENCES

• Naisbitt DJ et al. J Pharmacol Exp Ther. 2005 Jun