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Phenindione

Catalog No. S1921 Name Selleck Chemicals
CAS Number 83-12-5 Website http://www.selleckchem.com
M. F. C15H10O2 Telephone (877) 796-6397
M. W. 222.2387 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 381

SYNONYMS

IUPAC name
2-phenyl-2,3-dihydro-1H-indene-1,3-dione
IUPAC Traditional name
phenindione
Synonyms
Rectadione
Dindevan

DATABASE IDS

CAS Number 83-12-5

PROPERTIES

Salt Data Free Base
Storage Condition -20°C

DETAILS

Description (English)
Research Area: Immunology, Cardiovascular Disease
Biological Activity:
Phenindione(Rectadione) is an anticoagulant which functions as a Vitamin K antagonist. A lymphocyte transformation test showed proliferation of T-cells from the hypersensitive patient, but not from four controls on exposure to phenindione in vitro. Drug-specific T-cell clones were generated and characterized in terms of their phenotype, functionality, and mechanism of antigen presentation. Forty-three human leukocyte antigen class II restricted CD4+ αβ T-cell clones were identified. T-cell activation resulted in the secretion of interferon-γ and interleukin-5. [1][2]

REFERENCES

  • Naisbitt DJ et al. J Pharmacol Exp Ther. 2005 Jun