Diclofenac

• Catalog No.: S1903
• CAS Number: 15307-79-6
• M. F.: C14H10Cl2NNaO2
• M. W.: 318.13047
• Storage: -20°C

SYNONYMS

• IUPAC name: sodium 2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetate
• IUPAC Traditional name: sodium diclofenac(1-)
• Synonyms: Benfofen; Voltaren; Solaraze; Ecofenac

DATABASE IDS

• CAS Number: 15307-79-6

PROPERTIES

• Target: COX
• Salt Data: sodium salt
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: cancer
Biological Activity:
Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 µM, respectively. It is thought that the primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX), and it appears to inhibit DNA synthesis. [1][2]

REFERENCES

• http://en.wikipedia.org/wiki/Diclofenac
• Patrignani P et al. J Physiol Pharmacol. 1997 Dec;48(4):623-31.