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Hydroxyurea

Catalog No. S1896 Name Selleck Chemicals
CAS Number 127-07-1 Website http://www.selleckchem.com
M. F. CH4N2O2 Telephone (877) 796-6397
M. W. 76.05466 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 878

SYNONYMS

IUPAC name
hydroxyurea
IUPAC Traditional name
hydroxyurea
Synonyms
Hydrea
Cytodrox
Biosupressin

DATABASE IDS

CAS Number 127-07-1

PROPERTIES

Salt Data Free Base
Solubility DMSO
Storage Condition -20°C

DETAILS

Description (English)
Research Area: Cancer
Biological Activity:
Hydroxyurea(Cytodrox) is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea is converted to a free radical nitroxide (NO) in vivo, and transported by diffusion into cells where it quenches the tyrosyl free radical at the active site of the M2 protein subunit of ribonucleotide reductase, inactivating the enzyme. The entire replicase complex, including ribonucleotide reductase, is inactivated and DNA synthesis is selectively inhibited, producing cell death in S phase and synchronization of the fraction of cells that survive. Repair of DNA damaged by chemicals or irradiation is also inhibited by hydroxyurea, offering potential synergy between hydroxyurea and radiation or alkylating agents. Hydroxyurea also increases the level of fetal hemoglobin, leading to a reduction in the incidence of vasoocclusive crises in sickle cell anemia. Levels of fetal hemoglobin increase in response to activation of soluble guanylyl cyclase (sGC) by hydroxyurea-derived NO. [1]

REFERENCES

  • http://www.drugbank.ca/drugs/DB01005