Nizatidine

• Catalog No.: S1890
• CAS Number: 76963-41-2
• M. F.: C12H21N5O2S2
• M. W.: 331.45744
• Storage: -20°C

SYNONYMS

• IUPAC name: dimethyl[(4-{[(2-{[(Z)-1-(methylamino)-2-nitroethenyl]amino}ethyl)sulfanyl]methyl}-1,3-thiazol-2-yl)methyl]amine
• IUPAC Traditional name: dimethyl[(4-{[(2-{[(Z)-1-(methylamino)-2-nitroethenyl]amino}ethyl)sulfanyl]methyl}-1,3-thiazol-2-yl)methyl]amine
• Synonyms: Tazac; Axid AR; Axid

DATABASE IDS

• CAS Number: 76963-41-2

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Metabolic Disease
Biological Activity:
Nizatidine is a histamine H2-receptor antagonist with and IC50 of 6.7 nM for AChE. [1] It inhibits stomach acid production, and commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). The relative anti-AChE potency was in the following order: neostigmine > nizatidine >cimetidine >> famotidine. The inhibition of AChE by nizatidine was noncompetitive, with a Ki value of 7.4 x 10 nM. Gastrointestinal (GI) motility was examined during the interdigestive state in dogs with chronically implanted force transducers. [2]

REFERENCES

• Ueki S et al. J Pharmacol Exp Ther. 1993 Jan;264