Mitoxantrone Hydrochloride

• Catalog No.: S1889
• CAS Number: 70476-82-3
• M. F.: C22H30Cl2N4O6
• M. W.: 517.4028
• Storage: -20°C

SYNONYMS

• IUPAC name: 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-dihydroanthracene-9,10-dione dihydrochloride
• IUPAC Traditional name: mitoxantrone dihydrochloride
• Synonyms: Novantrone; NSC-310739

DATABASE IDS

• CAS Number: 70476-82-3

PROPERTIES

• Target: DNA/RNA
• Salt Data: Hydrochloride
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Cancer
Biological Activity:
Mitoxantrone Hydrochloride (NSC301739; Immunex) is a hydrochloride salt of mitoxantrone which is a synthetic antineoplastic anthracenedione (IC50 = 0.42 mM).Mitoxantrone Hydrochloride (NSC301739; Immunex) is also a synthetic antineoplastic anthracenedione. Mitoxantrone Hydrochloride (NSC301739; Immunex) is a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone Hydrochloride (NSC301739; Immunex) also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA. Mitoxantrone Hydrochloride (NSC301739; Immunex) has a cytocidal effect on both proliferating and nonproliferating cultured human cells, suggesting lack of cell cycle phase specificity. [1][2]

REFERENCES

• Desai PB et al. Pharm Res. 1992 Feb; 9(2):178-81