1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone

• Catalog No.: L09968
• CAS Number: 7226-23-5
• M. F.: C6H12N2O
• M. W.: 128.17228
• Purity: 98%

SYNONYMS

• Title: 1,3-二甲基-3,4,5,6-四氢-2(1H)-嘧啶酮
• IUPAC name: 1,3-dimethyl-1,3-diazinan-2-one
• IUPAC Traditional name: DMPU
• Synonyms: N,N'-Dimethylpropyleneurea; DMPU

DATABASE IDS

• CAS Number: 7226-23-5
• Beilstein Number: 110562
• MDL Number: MFCD00006550
• EC Number: 230-625-6

PROPERTIES

• Purity: 98%
• Boiling Point: 246-247°C
• Density: 1.060
• Flash Point: 120°C(248°F)
• Melting Point: -23°C
• Refractive Index: 1.4890
• GHS Hazard statements: H301-H318-H361
• European Hazard Symbols: X
• GHS Precautionary statements: P280-P301+P310-P305+P351+P338-P321-P405-P501A
• Risk Statements: 22-41-62
• RTECS: UW7582500
• Safety Statements: 26-36/37/39
• Storage Warning: Hygroscopic
• TSCA Listed: 是

REFERENCES

• Dipolar aprotic solvent recommended as a replacement for the carcinogenic hexamethylphosphoric triamide (HMPA) in many reactions: Helv. Chim. Acta, 65, 385 (1982). DMPU is non-mutagenic: Chimia, 39, 148 (1985). It is more useful than the lower homologue 1,3-Dimethyl-2-imidazolidinone, A16001 (mp 8^oC) for low-temperature reactions. Can be used as a general replacement for HMPA in organolithium reactions: J. Am. Chem. Soc., 107, 719 (1985).
• Has been found to be comparable to HMPA in promoting reductive coupling reactions with SmI₂: J. Am. Chem. Soc., 110, 5064 (1988); J. Chem. Soc., Chem. Commun., 1775 (1992), and also in other reductions with the same reagent: J. Org. Chem., 58, 5008 (1993).